Journal article
Assessing the Incremental Contribution of Common Genomic Variants to Melanoma Risk Prediction in Two Population-Based Studies
AE Cust, M Drummond, PA Kanetsky, GJ Mann, H Schmid, JL Hopper, JF Aitken, BK Armstrong, GG Giles, E Holland, RF Kefford, MA Jenkins, JA Newton Bishop, P Affleck, JH Barrett, DT Bishop, J Harrison, MM Iles, J Randerson-Moor, M Harland Show all
Journal of Investigative Dermatology | ELSEVIER SCIENCE INC | Published : 2018
Abstract
It is unclear to what degree genomic and traditional (phenotypic and environmental) risk factors overlap in their prediction of melanoma risk. We evaluated the incremental contribution of common genomic variants (in pigmentation, nevus, and other pathways) and their overlap with traditional risk factors, using data from two population-based case-control studies from Australia (n = 1,035) and the United Kingdom (n = 1,460) that used the same questionnaires. Polygenic risk scores were derived from 21 gene regions associated with melanoma and odds ratios from published meta-analyses. Logistic regression models were adjusted for age, sex, center, and ancestry. Adding the polygenic risk score to ..
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Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (566946, 107359, 211172, 402761), the Cancer Council New South Wales (77/00, 06/10), Cancer Council Victoria, Cancer Council Queensland (371), and the US National Institutes of Health (NIH grant RO1 CA83115 to the international Melanoma Genetics Consortium [GenoMEL]). The Leeds group was funded by program grant from Cancer ResearchUK C588/A19167 and EU under Framework 6 LSHM-CT-2005-018702. AEC received Career Development Fellowships from the NHMRC (1147843) and Cancer Institute NSW (15/CDF/1-14). This research was supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics.